By Tony Moss, NFL Editor -- (Sports Network) - In their next-to-last game of the preseason, generally held up as the dress rehearsal for the regular season opener, the Indianapolis Colts will be at less than 100 percent.

And, though face-of-the-franchise Peyton Manning will be missing when the Buffalo Bills help inaugurate Lucas Oil Stadium on Sunday night, the Colts are undoubtedly getting healthier.

Defensive end Dwight Freeney (foot) and safety Bob Sanders (shoulder), both of whom have missed the entire preseason to date, have a chance to play against the Bills. If Freeney is able to see action, it will be his first appearance since suffering a season-ending foot injury in a loss to the Chargers last Nov. 11th. The oft-injured Sanders, meanwhile, had shoulder surgery in January and just recently returned to the practice field.

But the big personnel story for Indy will remain Manning, who had an infected bursa sac removed from his left knee on July 14th and appears unlikely to suit up in the preseason.

Backup Jim Sorgi, who helped lead Ton Dungy's squad to a 16-9 win at Atlanta last Saturday, will once again get the starting nod for the Colts. Sorgi was 7-of-12 for 67 yards in the victory, which was just Indianapolis' third triumph in its last 16 preseason contests.

Newcomers Quinn Gray and Jared Lorenzen, who are fighting for the No. 3 job behind Manning and Sorgi, will likely see time in the second half against the Bills.

While Indianapolis looks to maintain the health of its star defenders, the Bills will come into the Circle City trying to build on the positive momentum gleaned from last Thursday's 24-21 win over the Steelers.

Starting quarterback Trent Edwards shook off the rust of a weak outing in the preseason opener, completing 9-of-11 passes for 104 yards and two touchdowns before exiting. Tight end Robert Royal was the recipient of both Edwards TD passes.

The Bills also received a thrilling moment from rookie and first-round draft choice Leodis McKelvin, whose 95-yard kickoff return for a touchdown in the third quarter helped lift Buffalo to the win.

Edwards is considered questionable for Sunday after colliding with running back Marshawn Lynch in practice earlier in the week. Edwards' injury is not believed to be serious, but he did sustain some knee soreness.

Linebacker Angelo Crowell (knee) and wideout James Hardy (hamstring) are other Bills notables who could be held out against Indianapolis. Left tackle Jason Peters (contract holdout) is not expected to be in attendance.

Whatever happens on the field Sunday night figures to be overshadowed by the venue itself. Lucas Oil Stadium, a 63,000-seat, retractable-roof facility that cost a reported $720 million to build, will be hosting a major event for the first time. The facility replaces the RCA Dome, which had been the Colts' home since their move from Baltimore in 1984, as the team's field.

Indianapolis has a 3-1 edge in its all-time preseason series with Buffalo, but was a 17-10 home loser to its former division rival in the last such meeting, prior to the 2005 season.