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2008 Massachusetts Minutemen Schedule
| Date | Time (ET) | Opponent | Result | Record |
| 08/30/2008 | 06:00 PM | Albany | W, 28-16 | 1-0-0 |
| 09/06/2008 | 01:00 PM | at Holy Cross | W, 45-42 | 2-0-0 |
| 09/13/2008 | 03:30 PM | at James Madison | L, 52-38 | 2-1-0 |
| 09/20/2008 | 07:00 PM | at Texas Tech | L, 56-14 | 2-2-0 |
| 10/04/2008 | 03:30 PM | Delaware | W, 17-7 | 3-2-0 |
| 10/11/2008 | 12:00 PM | at Northeastern | W, 28-24 | 4-2-0 |
| 10/18/2008 | 03:30 PM | Richmond | L, 30-15 | 4-3-0 |
| 10/25/2008 | 01:00 PM | Bryant | W, 42-7 | 5-3-0 |
| 11/01/2008 | 12:00 PM | at Rhode Island | W, 49-0 | 6-3-0 |
| 11/08/2008 | 12:00 PM | Maine | L, 21-20 | 6-4-0 |
| 11/15/2008 | 12:00 PM | at New Hampshire | L, 52-21 | 6-5-0 |
| 11/22/2008 | 02:30 PM | Hofstra | W, 28-14 | 7-5-0 |
